calcium sensing receptor (CaSR)

By Targets:	CaSR (17) mGluR (1) TNF Receptor (1) Wnt (1)
By Research Areas:	Cardiovascular Disease (3) Endocrinology (5) Inflammation/Immunology (1) Metabolic Disease (9) Neurological Disease (2)

Targets Recommended: CaSR Calcium Channel Calmodulin CRAC Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122819

Calindol hydrochloride	CaSR	Cardiovascular Disease
Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic **calcium-sensing receptor (CaSR) with an EC₅₀** of 132 nM .

HY-103314

Gadolinium chloride GdCl3	CaSR	Cardiovascular Disease
Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research of cardiovascular disease .

HY-11095

NPS 2390	mGluR CaSR	Cardiovascular Disease Neurological Disease
NPS 2390 is a noncompetitive antagonist of mGluR1 and mGluR5 . NPS 2390 is also a potent CaSR (calcium-sensing receptor) inhibitor .

HY-153258

CaSR antagonist-1	CaSR	Metabolic Disease
CaSR antagonist-1 is a calcium sensing receptor *(CaSR)* antagonist with an IC₅₀ value of 50 nM. CaSR antagonist-1 can be used for the research of disorders associated with abnormal bone or mineral homeostasis such as osteoporosis .

HY-P4376

Gamma-Glu-Abu

CaSR Neurological Disease

Gamma-Glu-Abu is a potent calcium sensing receptor (CaSR) agonist .

Gamma-Glu-Abu	CaSR	Neurological Disease
Gamma-Glu-Abu is a potent **calcium sensing receptor (CaSR)** agonist .

HY-N0546

Ligustroflavone Nuezhenoside	CaSR	Metabolic Disease
Ligustroflavone, extracted from Ligustrum lucidum, is a potential candidate as **calcium-sensing receptor (CaSR)** antagonist. Ligustroflavone exhibits protective effects against diabetic osteoporosis in mice .

HY-P1955

Etelcalcetide AMG 416; KAI-4169	CaSR	Endocrinology
Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the **calcium sensing receptor (CaSR)**. Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis .

HY-P1955A

Etelcalcetide hydrochloride 1 Publications Verification AMG 416 hydrochloride; KAI-4169 hydrochloride	CaSR	Endocrinology
Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide as an activator of the **calcium sensing receptor (CaSR)**. Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis .

HY-10167A

Tecalcet Hydrochloride 3 Publications Verification R-568 hydrochloride	CaSR	Others
Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the **calcium-sensing receptor (CaSR)**. Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca ²⁺ .

HY-17613

Evocalcet 1 Publications Verification KHK7580	CaSR	Metabolic Disease
Evocalcet (KHK7580) is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism .

HY-117851

AC-265347	CaSR	Metabolic Disease Endocrinology
AC-265347 is a **calcium-sensing receptor** (CaSR) agonist and positive allosteric modulator (ago-PAM) with the functional affinity (pK_B) of 5.1. AC-265347 can be used for the research of hyperparathyroidism and related diseases .

HY-14752

Ronacaleret SB 751689	CaSR	Metabolic Disease Endocrinology
Ronacaleret (SB 751689) is an orally active, potent, and selective **calcium-sensing receptor (CaSR)** antagonist that stimulates endogenous parathyroid hormone release from the parathyroid glands. Ronacaleret (SB 751689) is used for the study of postmenopausal osteoporosis .

HY-15104

Ronacaleret hydrochloride SB 751689A	CaSR	Metabolic Disease Endocrinology
Ronacaleret hydrochloride (SB 751689A) is an orally active, potent, and selective **calcium-sensing receptor (CaSR)** antagonist that stimulates endogenous parathyroid hormone release from the parathyroid glands. Ronacaleret hydrochloride (SB 751689A) is used for the study of postmenopausal osteoporosis .

HY-10171

NPS-2143 hydrochloride Maximum Cited Publications 15 Publications Verification SB-262470A hydrochloride	CaSR	Metabolic Disease
NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent **calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca ²⁺ concentrations (IC₅₀*=43 nM) elicited by activating the Ca ²⁺ receptor* in HEK 293 cells expressing the human Ca ²⁺ receptor .

HY-10007

NPS-2143 Maximum Cited Publications 15 Publications Verification SB-262470A	CaSR	Metabolic Disease
NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent **calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca ²⁺ concentrations (IC₅₀*=43 nM) elicited by activating the Ca ²⁺ receptor* in HEK 293 cells expressing the human Ca ²⁺ receptor .

HY-17397

Strontium Ranelate 2 Publications Verification Distrontium renelate; S12911	CaSR	Metabolic Disease
Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the **calcium-sensing receptor (CaSR)** in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling .

HY-12557

γ-Glutamylvaline	CaSR Wnt TNF Receptor	Inflammation/Immunology
γ-Glutamylvaline is an activator of *CaSR* with anti-inflammatory activity. γ-Glutamylvaline inhibits TNF-α-induced proinflammatory cytokine production and increases Wnt5a expression. γ-Glutamylvaline activates calcium-sensing receptor pathways in adipocytes of 3T3-L1 mice and prevents low-grade chronic inflammation .

Cat. No.	Product Name	Target	Research Area

HY-P1955A

Etelcalcetide hydrochloride 1 Publications Verification AMG 416 hydrochloride; KAI-4169 hydrochloride	CaSR	Endocrinology
Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide as an activator of the **calcium sensing receptor (CaSR)**. Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis .

HY-12557

γ-Glutamylvaline	CaSR Wnt TNF Receptor	Inflammation/Immunology
γ-Glutamylvaline is an activator of *CaSR* with anti-inflammatory activity. γ-Glutamylvaline inhibits TNF-α-induced proinflammatory cytokine production and increases Wnt5a expression. γ-Glutamylvaline activates calcium-sensing receptor pathways in adipocytes of 3T3-L1 mice and prevents low-grade chronic inflammation .

HY-P4376

Gamma-Glu-Abu

CaSR Neurological Disease

Gamma-Glu-Abu is a potent calcium sensing receptor (CaSR) agonist .

Gamma-Glu-Abu	CaSR	Neurological Disease
Gamma-Glu-Abu is a potent **calcium sensing receptor (CaSR)** agonist .

HY-P1955

Etelcalcetide AMG 416; KAI-4169	CaSR	Endocrinology
Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the **calcium sensing receptor (CaSR)**. Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0546

Ligustroflavone Nuezhenoside	Flavonoids Classification of Application Fields Oleaceae Flavones Ligustrum lucidum Ait. Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	CaSR
Ligustroflavone, extracted from Ligustrum lucidum, is a potential candidate as **calcium-sensing receptor (CaSR)** antagonist. Ligustroflavone exhibits protective effects against diabetic osteoporosis in mice .

Cat. No.	Compare	Product Name	Species	Source

HY-P79408

	Calcium-sensing R/CaSR Protein, Human (HEK293, His) Extracellular calcium-sensing receptor; CASR; CaR; hCasR; Parathyroid cell calcium-sensing receptor 1; PCaR1; calcium-sensing receptor	Human	HEK293
	Calcium-sensing receptor (CaSR) is a G-protein-coupled receptor that is essential for maintaining calcium homeostasis. It senses changes in extracellular calcium concentration, regulates parathyroid hormone (PTH) production, and activates the phosphatidylinositol-calcium second messenger system. Calcium-sensing R/CaSR Protein, Human (HEK293, His) is the recombinant human-derived Calcium-sensing R/CaSR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Calcium-sensing R/CaSR Protein, Human (HEK293, His) is 582 a.a., with molecular weight of approximately 95-130 kDa.


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calcium sensing receptor (CaSR)

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